Daily LD PK Simulator

Rytary (IPX066) + IR CD-LD · Bateman PK · PD patient correction · All inputs update chart live
Peak LD
—
ng/mL
Min Trough
—
ng/mL
Time <810
—
hrs/day
Time >2800
—
hrs/day
24-Hour Levodopa Plasma Concentration
—
—
Rytary + rescues (total)
Rytary only (no rescues)
Equiv IR overlay
Therapeutic ≥810
High risk ≥2800
Dysk EC50 600
Scheduled Doses ⌄
Morning245+145+95 default
mg
Noon245+145+95 default
mg
Evening245+145+145 default
mg
Bedtime245+145+95+95 default
mg
Modifiers ⌄
Show equivalent IR CD-LD overlayDashed yellow — same LD doses, IR kinetics (sharp peaks, fast drop)
High-fat breakfast with morning doseDelays Tmax +2hr, Cmax −21% (Yao et al. 2016)
High-protein meal near any doseBBB amino acid competition → ~20% CNS reduction
Poor sleep / high stressRaises effective thresholds ~120 ng/mL
PK profile
Rescue / PRN Doses · added to main curve ⌄
PK model: Bateman 1-compartment, unit-corrected (mg×1000/L = ng/mL). CL/F=56.8 L/hr, V/F=114.4 L, ke=0.497 hr⁻¹ (FDA NDA 203312). Rytary tri-phasic: ka_IR=3.2, ka_ER1=0.55, ka_ER2=0.18 hr⁻¹ (fractions 27/48/25%). IR CD-LD: ka=3.5 hr⁻¹. PD correction +38% Cmax. Food effect: Yao et al. 2016. EC50: Mao et al. 2013. Semi-quantitative — not a substitute for clinical judgment. Intrasubject variability ±20%.